Traditional Chinese medication (TCM) has analgesic and anti-inflammatory effects in patients with knee osteoarthritis (OA). performance and wellness, was also measured. Two researchers independently extracted data on study design, population characteristics, duration, intervention, outcomes, risk of bias, and primary results. We performed a random-effects meta-analysis when appropriate. We also explored factors that could explain the heterogeneity by conducting subgroup and meta-regression analyses. Twenty-three studies, totaling 2362 subjects, met the eligibility criteria. Treatments were formulated with an average of 8 Chinese herbs and were prescribed based on the traditional Chinese diagnostic method of syndrome differentiation. The mean treatment duration was seven weeks, with oral administration occurring one to three times a day. Compared with nonsteroidal anti-inflammatory drugs and intra-articular hyaluronate injections, 18 of the studies showed significantly improved VAS pain scores (Mean Difference [MD] = 0.56; 95% confidence interval [CI], 0.18 to 0.94; = 0.004), six of the studies showed significantly improved WOMAC pain subscale scores (MD = 2.23; 95% CI, 0.56 to 3.91; = 0.009), and 16 of the trials showed significantly improved total effectiveness rates (risk ratio = 1.12; 95% CI, 1.05 to at least one 1.19; = 0.0003). Furthermore, TCM demonstrated a lower threat of adverse occasions than regular western remedies. This evidence shows that TCM can be effective and safe for improving discomfort, function, and wellness in remedies of knee OA. Nevertheless, there can be inherent medical heterogeneity (varied TCM formulations, settings, and treatment regimens) among the included trials. Despite these restrictions, the potential analgesic ramifications of TCM warrant additional methodologically rigorous study to look for the medical implications of TCM on discomfort administration in knee OA. Worth(2005)ACR knee OA criteria (1986)60 (68%)63132Blood-nourishing and hard-softening capsule (Elements: White colored peony root, Largeleaf Gentian Root and Liquoric Root), Celecoxib ic50 1.05 g, 3 x a day. 4 wks/1 program.Glucosamine, 750 mg, 3 x a day. 4 wks/1 program.VAS Discomfort WOMAC Pain1.8 vs. 2.0(2008)ACR knee OA criteria (1986)50 (60%)59132Tong Bi Granule (Elements: Doubleteeth pubescent angilica root, Chinese Angelica, Twotooth achyranthes root, Giant Knotweed Rhizome, Chinese Taxillus Twig, Epimedium Herb, etc.), 3 x a day. 6 wks/1 program.Glucosamine, 250 mg 3 x a day. 6 wks/1 program.VAS Discomfort Total effectiveness price2.6 vs. 3.4(2009)ACR knee OA criteria (1986)118 (90%)5284Self-made Decoction (Elements: Peach Seed 10 g, Safflower 12 g, Szechuan Lovage Rhizome 10 g, Chinese Angelica 12 g, Crimson Paeony Root 10 g, Twotooth Achyranthes Root 12 g, Chinese Taxillus Twig 15 g, Eucommia Bark 12 g, Clematis Root 12 g), 3 x a day. 12 wks/1 program.Celecoxib, Celecoxib ic50 200 mg, once a day time. 12wks/1 course.VAS Discomfort Total effectiveness price2.41 vs. 3.18(2009)ACR knee OA criteria (1986)337 (56%)5560Yang Yuan Rou Gan Decoction (Ingredients: Astragalus root 30 g, Rehmannia Root 20 g, Malaytea Scurfpea Fruit 15 g, White peony root 30 g, Ginseng 15 g, Tuber Fleeceflower Root Celecoxib ic50 12 g, Chinese Angelical 2 g, Desertliving Cistanche 10 g, Fortunes Drynaria Rhizome 10 g, Chinese Thorowax Root 10 g, Dendrobium 30 g, Common Floweringquince Fruit 10 g, Celecoxib ic50 Twotooth Achyranthes Root 10 g, Liquoric Root 10 g), twice a day time. 1 month/1 course.Glucosamine, 750 mg, 3 x a day. 1 month/1 program.VAS Discomfort Total effectiveness price1.22 vs. 2.46(2009)ACR knee OA criteria (1986)60 (58%)5376Decoction of suppling qi and activating blood vessels circulation (Ingredients: Astragalus root 30 g, Pilose Asiabell Root 30 g, Largehead Atractylodes Rhizome 20 g, Suberect Spatholobus Stem 30 g, Donkey-hide Glue 15 g, Szechuan Lovage Rhizome 15 g, White peony root 20 g, Chinese Angelica 15 g, Costustoot 6 g, Chinese Thorowax Root 12 g, Chinese Starjasmine Stem 20 g, Clematis Root 30 g), twice a day time. 2 courses, 3 months/1 program.Celecoxib, 100 mg, twice a day time. 2 courses, 3 months/1 program.WOMAC Pain6.03 vs. 7.14 Rabbit Polyclonal to ZFHX3 0.01Xie (2010)ACR knee OA requirements (1986)176 (81%)6096Self-made Decoction (Elements: Amur Corktree Bark 0.5 g, Coix Seed 1.4 g, Swordlike Atractylodes Rhizome 2.2g, Largehead Atractylodes Rhizome 3.0 g, Radix Stephaniae Tehrandrae 0.6 g, Salviae miltiorrhizae 1.8 g, Indian Buead 0.5 g, Doubleteeth Pubescent Angilica Root 2.5 g, Chinese Taxillus Twig 0.9 g, Twotooth Achyranthes Root 2.5 g), twice a day. 4.