Background To compare the magnetic resonance imaging (MRI) top features of ovarian very clear cell carcinoma (CCC) and high-grade serous carcinoma (HGSC), to tell apart CCC from HGSC. 83?% (24/29) of HGSCs (<0.001) (Fig.?5). The improvement was minor in 5?%, moderate in 17?% and prominent in 78?% of CCCs versus 3?%, 13?%, 84?% of HGSCs, respectively (<0.001). Using binary logistic regression evaluation, the most important predictive top features of CCC had been a unilocular cystic mass (Chances proportion[OR]?=?19.9, 95?% self-confidence period [CI]: 5.4C74.1), oval form (OR?=?12.5, 95?%; 4.8C32.4), good sized papillary projections Mouse monoclonal to IL-8 (OR?=?9.5, 95?% CI: 1.2C88.4), and hyperintensity on T1WI (OR?=?8.5, 95?% CI: 2.5C28.7). Desk 2 Evaluation of MRI features between HGSC and CCC Fig. 1 A 53-year-old girl with still left ovarian apparent cell carcinoma (CCC). Sagittal and Axial turbo spin echo (TSE) T2-weighted imaging (T2WI) with fats saturation (FS) (a-b) present an oval unilocular cystic mass with papillary projections (arrows). Axial and sagittal … Fig. 2 A 50-year-old girl with bilateral high-grade serous carcinoma 941685-27-4 IC50 (HGSC). Axial and sagittal TSE T2WI with FS (a-b), axial T1WI (c) and sagittal contrast-enhanced display 2D T1WI with FS (d) present the abnormal solid mass appearing with iso-intensity on T1WI … Fig. 3 An 81-year-old woman with CCC in the left ovary. Axial SE T1WI, axial and sagittal TSE T2WI with FS (a, b, c) demonstrate a unilocular cystic mass with 941685-27-4 IC50 a large papillary projection, with prominent enhancement on contrast-enhanced flash 2D T1WI with FS … Fig. 4 A 42-year-old woman with HGSC in the right ovary. Axial SE T1WI and TSE T2WI with FS (a-b) show a mulitlocular cystic mass with multiple small papillary projections. Axial and sagittal contrast-enhanced flash 2D T1WI with FS (c-d) show the prominently … Fig. 5 A 49-year-old woman with CCC in the right ovary. Axial SE T1WI, axial and sagittal TSE T2WI with FS (a-c) demonstrate a unilocular cystic mass with multiple papillary projections (arrows). The transmission intensity of the cystic component is usually high on both T1WI … Diagnostic performances for the characterization of CCC are outlined in Table?3. The combination of any two of four features — a unilocular cystic mass, oval shape, large papillary projections (4?cm) and hyperintensity on T1WI — yielded sensitivity, specificity, accuracy, positive and negative predictive values, and a positive likelihood ratio for identifying CCC of 90?% (36/40), 87?% (54/62), 88?% (90/102), 82?% (36/44), 93?% (54/58), and 6.92, respectively. Table 3 Diagnostic overall performance of MRI features for characterizing ovarian CCC Conversation Ovarian carcinomas comprise a heterogeneous group of tumors, the four most common subtypes being serous, endometrioid, obvious cell and mucinous. In recent years, considerable improvements have been achieved in the understanding and identification of the underlying pathogenesis in different subtypes [1, 14]. Our previous study showed that standard MRI combining DWI may be helpful for differentiating ovarian endometrioid carcinomas from HGSC [15]. Previous studies have indicated that there are different risk factors, origins, genetic alterations, 941685-27-4 IC50 biological behaviors, clinicopathological characteristics and chemotherapy sensitivities between ovarian CCC and HGSC [2C6, 16]. In our clinical practice, we also have found the MRI features between CCC and HGSC may be different. So we try to investigate the characteristic features of CCC and to evaluate MRI for distinguishing CCC from HGSC. Clinically, patients with CCC are more likely to present with a unilateral (89C95?%), large pelvic mass (12?cmC13.5?cm) and stage I disease (56C63?%) in association with endometriosis (31C48?%) [5, 17, 18]. In contrast, individuals with HGSC are more likely to be present having a bilateral (50?%), medium-sized mass (8.6?cm) and advanced stage disease (81?%) [5, 17]. In this study, significant differences were found in unilaterality (91?% vs 55?%), mass size (11.4?cm vs 8.6?cm) and stage I disease (62?% vs 10?%) between ovarian CCCs and HGSCs. Ovarian CCCs were confirmed to become derived from the endometriosis in 25?% of the individuals,.