Plasma B-type natriuretic peptide (BNP) can be used as a diagnostic

Plasma B-type natriuretic peptide (BNP) can be used as a diagnostic marker of cardiovascular diseases. volume. According to multiple regression analysis, CE group, female gender, and infarction volume were independently associated with plasma BNP. Plasma BNP level showed statistically significant differences among LAA (n = 71), CE (n = 50), and SA (n = 20) groups (p <0.001), and the expression decreased in order of CE (253.8 337.1 pg/mL), LAA (61.6 78.8 pg/mL), and SA (25.3 24.8 pg/mL). Increased plasma BNP correlated with increased infarction volume (r = 0.42, p <0.001). Conclusions: Plasma BNP may be helpful for prediction of etiologic classification of acute cerebral infarction and infarction volume. Keywords: cerebral infarction, brain natriuretic peptide, etiology, cardiovascular diseases, embolism, infarction volume Introduction B-type natriuretic peptide (BNP) belongs to a family of natriuretic peptides and is involved in the regulation of various physiologic functions such as natriuresis, diuresis, and vasodilation 1. Plasma BNP is usually increased in edematous disorders with salt and fluid overload and increased atrial or ventricular wall tension 2. Increased plasma BNP is usually a known marker of cardiovascular diseases 1-4. Plasma BNP level is frequently elevated in acute cerebral infarction and has been associated with cardiac dysfunction, clinical severity, and poor prognosis of cerebral infarction 5-10. The purpose of this research was to research plasma BNP in sufferers with severe cerebral infarction regarding to variables such as for example infarction subtype and infarction quantity. Patients and Strategies Among 236 consecutive sufferers with severe cerebral infarction who had been accepted within three times of starting point and whose bloodstream samples had been obtained during initial laboratory research, 141 sufferers had been enrolled and classified as belonging to the large artery atherosclerosis (LAA), cardioembolism (CE), and small vessel disease (SA) groups according to the Trial of Org 10172 in Acute Stroke Treatment (TOAST) classification 11. Patients with renal dysfunction (serum creatinine >2.5 mg/dL), dialysis dependent renal failure, pulmonary disease 874101-00-5 manufacture such as acute respiratory distress syndrome, chronic obstructive pulmonary disease with cor pulmonale and pulmonary embolism, or thrombolytic therapy were excluded from the study. Blood was obtained before treatment, and patients were assessed by the National Institute of Health Stroke Level (NIHSS). Demographic characteristics such IL10B as age, gender, smoking, and medical history of hypertension, diabetes mellitus, cardiac disease, and hyperlipidemia were recorded. Blood pressure, heart rate, chest X-ray, electrocardiography, and blood assessments including hemoglobin, white blood cell (WBC) count, sugar, cholesterol, blood urea nitrogen, creatinine, BNP, and high sensitivity C-reactive protein (hs-CRP) were 874101-00-5 manufacture measured. Plasma BNP levels were measured by commercially available immunoassay (Biosite Inc., San Diego, CA, USA). Age- 874101-00-5 manufacture and sex-matched normal controls who frequented the health care center during the same period were included. The institutional review table approved this study, and knowledgeable consent was obtained from the patients or patients’ surrogates. During admission, brain MRI was performed with a 1.5-T system (Gyroscan Intera, Philips Medical Systems) using a multi-slice echo-planar imaging technique to acquire diffusion weighted images (DWIs). The imaging parameters of DWI were as follows: 3400/60/4 (repetition time, msec/effective echo time, msec/excitation), 24 cm field of view, 5/2 mm slice thickness/space, and 128128 matrix. B values were 0 and 1000 s/mm2. For the acquisition of the apparent diffusion coefficient, the images were applied in the x, y, and z directions. Acute cerebral infarction was defined as an certain section of high sign intensity over the DWI. Infarction quantity was computed by multiplying the personally contoured hyperintense area by the cut thickness in addition to the intersection difference using Scion image software program. Areas of severe infarction showed on DWI had been.

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